Donors graduate from the registry at 61 years old due primarily to medical reasons. 

Being part of the registry brings the potential to save someone’s life, an exciting prospect! That said, when people learn there is an age limit to donating, they often question why they are prohibited by such constraints when they feel so committed to potentially saving a life. 

Younger donors produce better outcomes for recipients

After over 60 years of stem cell and marrow transplants, knowledge on how to secure the best outcomes for patients has grown exponentially, including two key pieces of information: 

• The more stem cells transplanted, the higher the likelihood that those cells will start producing new marrow, blood, and immune cells.


• Younger donors produce more stem cells than older donors.

Thus, for the benefit of the patient, transplant centers prefer younger donors, as they produce higher quantities of cells. However, that isn’t the only age-related factor that transplant centers take into donor consideration. 

Donor health affects transplant time

Donors must be in excellent health at the time of donation for not only their safety but also to give the patient the best possible chance of success. As people age they generally accumulate more health problems which can result in an older donor being unavailable when a transplant is urgently needed. 

Health issues that impact the success of a transplant often are not detected until the donor is already in the workup process, forcing a delay while a new donor is found. Delaying a transplant puts the patient’s life in jeopardy. Doctors are often reluctant to proceed with an older donor if a younger one – who is less likely to have health issues – is available. 

Like every other system in the body, bone marrow ages. Structures at the end of chromosomes called telomeres limit the number of times a cell can reproduce. As people get older these telomeres get used up, and, without them, cells can no longer reproduce. Doctors are concerned that marrow from a 70-year-old donor transplanted into a 20-year-old patient may fail over time. 

Due to these factors, the World Marrow Donor Association requires donor registries to have an upper age limit not to exceed 60 years.  

But I still want to help!

Just because you graduate from the registry on your 61st birthday does not mean you can’t still help! In fact, Gift of Life needs your experience and skills more than ever. 

• Recruit: You can ask a younger donor to replace you in the registry. Invite your child or grandchild (aged 18 to 35) to join the registry. You can also invite Gift of Life to meet with an organization you and/or your family are involved with to set up a recruitment drive. Gift of Life works with many organizations across the Unites States and would be happy to set up a drive. 


• Advocate: Gift of Life needs people who believe in our mission to spread the word. If you love public speaking, help us by sharing your story with your community, with your colleagues, and with the media. If you’re a writer, jot down why you support Gift of Life – we’ll post your story on our website.


• Volunteer: Gift of Life can draw on your experience and expertise to help us as a volunteer. Gift of Life holds hundreds of donor recruitment drives and dozens of events every year, and the help of volunteers makes those events successful. Your expertise and experience in management, organization, motivation, and leadership skills are invaluable at these events. You can also volunteer at our office in Boca Raton as well.  


• Fundraise: Gift of Life is always raising funds to offset the laboratory processing of swab kits. Gift of Life is not government funded, and each kit costs $60 to tissue type. Whether its personal contributions or leveraging business connections to help with outreach, every effort is welcomed and appreciated. By starting your own Donor Circle, you can monitor your fundraising efforts and see, in real time, how many donors your contributions have sponsored, how many matches have been found, and how many transplants have resulted. 

Your relationship with Gift of Life does not end on your 61st birthday. If there are other ways you can help, then let us know! Call our corporate office at 561-982-2900 or 1-800-962-7769 and speak to our Volunteer Coordinator to learn more about how you can be involved.

Thank you for your past and future support of Gift of Life.

Dr. Bruce A. Lenes
Medical Director