Peripheral blood stem cell (PBSC) and marrow donation remains one of the most selfless acts anyone can do to save a life. However, despite more than half a century of donations, many myths remain about the process. Contrary to popular belief, anyone, regardless of gender, can donate PBSC or marrow, but there are some cases in which male donors are preferred by doctors and transplant centers.  

While males and females both donate regularly, males are often preferred as donors due to their physical size. On average, males are physically larger than females, resulting in larger bones and greater bone density – leading to a greater amount of marrow and therefore more blood volume. This means males usually produce higher blood stem cell yields during collection, which improves the success rate of a transplant. More blood stem cells transfused into a patient typically also decreases the number of days for the cells to begin producing new blood cells in the process known as engraftment. The quicker engraftment occurs, the more successful the outcome for the patient!

While the effect of donor sex continues to be debated amongst the scientific community, the fact that, on average, men yield more blood stem cells continues to be the driving factor for why they are preferred. 

Regardless of gender, people make the life-changing decision to donate every day and every donor’s contribution is invaluable in the fight against blood cancer and inherited immune diseases. Should you feel ready, we encourage you to join the registry, if you have not already, as your decision could save a patient's life in need. Anyone 18 to 35 years old and in general good health can join the registry by completing a cheek swab kit at an in-person donor recruitment drive or by ordering a kit sent to your home.